* Please note that the following agenda timings are Eastern Standard Time.
8:30 am
Join us for a coffee morning to meet your peers ahead of the conference
8:45 am Chair’s Opening Remarks
TGF-β in Immuno-Oncology: The Story So Far
9:00 am The Role of TGF-β in the Tumor Ecosystem & Immunotherapy
9:30 am An Overview of the TGF-β IO Market
10:00 am
Morning Networking Break
Synopsis
Meet and connect with your peers in this dedicated networking session.
Preclinical Track
Moving Beyond the Challenges of Preclinical Tumor Models
10:30 am Preclinical Models Reveal Heterogeneous Responses to TGF-β Antagonism & Highlight Potential Sites of Off-Tumor Toxicities
11:00 am Inhibition of Integrin αvβ8 in Combination with Low Dose Radiation Induces Antitumor Effect in Advanced Immune Checkpoint Blockade Refractory Tumor Model
11:30 am Therapeutic Inhibition of TGF-β Mediated Immune Suppression
Clinical Track
The Latest Clinical Advances
10:30 am BCA101, A Novel Dual-Action Antibody Combining the Precision Targeting of EGFR with the Immunomodulating Power of TGF-β
11:00 am Clinical Update on TST005
11:30 am Bintrafusp Afla: What, Why & How?
12:00 pm Networking Lunch
Novel Insights into Mechanisms of TGF-β Regulators
12:30 pm Impact of Dual TGF-β/PD-L1 Therapeutic Blockade on CD8 T Cell Phenotypes
1:00 pm How to Design Targetable Forms of TGF-β
1:30 pm Roundtable Discussion
Exploring the Clinical Landscape
12:30 pm Understanding the TGF-β Landscape
1:00 pm Optimizing Clinical Studies to Evaluate Safety & Tolerability
1:30 pm Roundtable Discussion
2:00 pm
Afternoon Networking Break & Poster Session
Synopsis
This scientific poster session is an opportunity to present your latest data and innovation. Submit your poster on the website in and share your breakthroughs with your peers.
Elevating Innovative Approaches to Regulation of TGF-β
2:30 pm Expression of a TGF-β Inhibitor from an Oncolytic Vaccinia Virus
3:00 pm Targeting Autotaxin – A Novel Approach to Interrupt TGF-β-Mediated Pathology
3:30 pm Discover the Potential of Integrin Inhibitors to Selectively Block TGF-β
4:00 pm Chair’s Closing Remarks
4:10 pm End of Day One
